The Outside View

An Insider’s View from the Outside

The discovery of ezetimibe: a view from outside the receptor.

The term “rationale drug design” has been used for more than 30 years to describe a marriage of experiment and technology intended to promote a more directed approach toward drug discovery, often focusing on whatever the hottest technology of the time might be.1 While the technology has changed over the years, the underlying goal has always been to provide a level of insight that would permit r...

The future of clinical research--an outside-in view.

Clinical academia is not in crisis--it has a rosy future if you really celebrate and respect it as an activity, if you ensure a supply of graduates committed to research, if you get the relationship right with your key partners, if you get the best facilities for prosecuting research, and finally if you use all the possibilities to ensure that academics are properly rewarded both in morale and ...

Evaluating ethics committees: a view from the outside.

More than 60 percent of hospitals have ethics committees. The wide-scale, voluntary adoption of these committees by hospitals is surprising, given the lack of data on their effectiveness. Little effort has been made to evaluate such committees, in part because of the lack of consensus on their purpose. The argument presented here is that, from a policy perspective, the committees' purpose must ...

V -A theory: a view from the outside

In this talk I will review the V -A theory within the context of the prevalent experimental results at the time. It is a great pleasure for me to be able to participate in this celebration in honor of Professor George Sudarshan. Let me say right away that unlike the other speakers in this session, I haven’t had the opportunity to collaborate with George yet. On the other hand, George is still y...